10 individually packed test cassettes for detection of rotavirus and adenovirus in human faecal specimens
Package contents:
10 test cassettes
10 specimen collection tubes with specimen diluent buffer
10 disposable pipettes
1 package insert
Exclusively for professional users
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The NADAL® Rota-Adenovirus Test is a rapid visual immuneassay for the qualitative detection of rotavirus and adenovirus in human faecal specimens. This test is intended to be used as an aid in the diagnosis of rotavirus and adenovirus infections. The test is designed for professional in-vitro diagnostic use only.
Rotavirus is the most common pathogen responsible for acute gastroenteritis, mainly in young children. Its discovery in 1973 and association with infantile gastroenteritis represented a very important advancement in the study of acute nonbacterial gastroenteritis. Rotavirus is transmitted by the orofaecal route with an incubation period of 1-3 days. Although specimens collected between the second and the fifth day of illness are ideal for antigen detection, rotavirus may still be detected while diarrhoea continues. Rotaviral gastroenteritis may result in mortality for populations at risk such as infants, the elderly and immunocompromised patients. In moderate climates, rotaviral infections occur mainly in the winter months. Endemics and epidemics affecting thousands of people have been reported. Up to 50% of the analysed specimens from hospitalised children suffering from acute entric disease were positive for rotavirus. The viruses replicate in the cell nucleus and tend to produce a characteristic cytopathic effect (CPE). Because rotavirus is extremely difficult to culture, it is unusual to isolate the virus for the diagnosis of iinfection. Instead, a variety of techniques have been developed to detect rotavirus in feces.
Acute diarrheal disease in young children is a major cause of morbidity worldwide and is a leading cause of mortality in developing countries. Research has shown that enteric adenoviruses, such as Ad40 and Ad41, are also one of the primary causes of diarrhoea in children, second only to rotaviruses. These viral pathogens have been identified throughout the world and can cause diarrhoea in children all year round. Infections are most frequently seen in children less than two years of age, but have also been found in patients of all ages. Further studies indicate that adenoviruses are associated with 4-15% of all hospitalized cases of viral gastroenteritis.
Rapid and accurate diagnosis of gastroenteritis caused by adenovirus is helpful in establishing the etiology of gastroenteritis and related patient management. Other diagnostic techniques such as electron microscopy (EM) and nucleic acid hybridization are expensive and labor-intensive. Due to the self-limited nature of adenoviral infection, such expensive and labor-intensive tests may not be necessary.
