20 individually packed test cassettes for detection Helicobacter pylori antigens in human faecal specimens
Package contents:
20 test cassettes
20 specimen dilution tubes with buffer
1 package insert
Exclusively for professional users
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The NADAL® H. pylori Ag Test (Faeces) is a rapid visual immunoassay for the qualitative presumptive detection of Helicobacter pylori (H.pylori) antigens in human faecal specimens. The NADAL® H. pylori Ag Test is intended to be used as an aid in the diagnosis of H. pylori infection.
H. pylori, also known as Campylobacter pylori, is a spiral-shaped, gram-negative bacterium with typical flagella. The bacterium infects the gastric mucosa by secreting the vacuolating cytotoxin A (VacA) and causes several gastroenteric diseases such as non-ulcerous dyspepsia, active gastritis or gastric and duodenal ulcer. H. pylori is classified as carcinogen agent type I and can increase the risk of stomach adenocarcinoma. Many H. pylori strains have been isolated. The one expressing the cytotoxin associated gene A (CagA) antigen is found to be highly immunogenic and is of utmost clinical importance because of its association with cytotoxic factors. It is widely reported in the specialist literature that infected patients possessing antibodies against CagA are at five times higher risk of gastric cancer than the reference group infected with a CagA negative bacterial strain. The presence of the CagA antibodies determines the persistence of H. pylori infection and ulceration. CagA antigen associated to others, such as CagII and CagC seems to act as a starting agent of a sudden inflammatory response, which may provoke peptic ulceration, allergic episodes and decrease the efficacy of therapy. At present several invasive and non-invasive methods are available to detect H. pylori infection. Invasive methods which require endoscopy of the gastric mucosa with a histologic, cultural and urease investigation are cost- and timeconsuming. Non-invasive methods include classical ELISA, immunoblotting assays and breath tests. But the latter are extremely complicated and highly unselective.
