20 individually packed test cassettes for detection of Helicobacter pylori (H. pylori) antigens in human faecal specimens
Package contents:
20 test cassettes
20 specimen collection tubes containing buffer
1 package insert
Exclusively for professional users
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The NADAL® H. pylori Ag Test is a lateral flow chromatographic immunoassay for the qualitative detection of Helicobacter pylori (H. pylori) antigens in human faecal specimens. The test is intended for use as an aid in the diagnosis of H. pylori infections. The test procedure is not automated and requires no special training or qualification. The NADAL® H. pylori Ag Test is designed for professional near-patient and laboratory use by healthcare professionals only.
H. pylori, also known as Campylobacter pylori, is a spiral-shaped, gram-negative bacterium with typical flagella. The bacterium infects the gastric mucosa by secreting the vacuolating cytotoxin A (VacA) and causes several gastroenteric diseases such as non-ulcerous dyspepsia, active gastritis or gastric and duodenal ulcer. H. pylori is classified as carcinogen agent type I and can increase the risk of stomach adenocarcinoma. Many H. pylori strains have been isolated. The one expressing the cytotoxin associated gene A (CagA) antigen is found to be highly immunogenic and is of utmost clinical importance because of its association with cytotoxic factors. It is widely reported in the specialist literature that infected patients possessing antibodies against CagA are at five times higher risk of gastric cancer than the reference group infected with a CagA negative bacterial strain. The presence of the CagA antibodies determines the persistence of H. pylori infection and ulceration. CagA antigen associated to others, such as CagII and CagC seems to act as a starting agent of a sudden inflammatory response, which may provoke peptic ulceration, allergic episodes and decrease the efficacy of therapy. At present several invasive and non-invasive methods are available to detect H. pylori infection. Invasive methods which require endoscopy of the gastric mucosa with a histologic, cultural and urease investigation are cost- and timeconsuming. Non-invasive methods include classical ELISA, immunoblotting assays and breath tests. But the latter are extremely complicated and highly unselective.
More Information
More Information
SKU
262902N-20
Testformat
test cassette
Test evaluation
Provides a qualitative test result
Sample type
Faeces
Detected parameter
H.pylori Ag
Package size
20 individually packed test cassettes
Detection time
Test result after 10 minutes
Storage temperature
The test should be stored at 2 - 30 °C
CE-Label
Yes
Pathogentype
Bacterial infection
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