10 individually packed test cassettes for the detection and differentiation of dengue virus NS1 antigens as well as anti-dengue virus IgG and IgM in human whole blood, serum or plasma specimens
Package contents:
10 test cassettes
10 disposable pipettes (40 μL) for Dengue NS1 Ag
10 capillary tubes (10 μL) for Dengue IgG/IgM
1 buffer (3 mL)
1 package insert
Exclusively for professional users
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The NADAL® Dengue NS1 Ag + IgG/IgM Test is a lateral flow chromatographic immunoassay for the qualitative detection and differentiation of dengue virus NS1 antigens as well as anti-dengue virus IgG and IgM in human whole blood, serum or plasma specimens. The test is intended for use as an aid in the diagnosis of primary andsecondary dengue virus infections in patients with febrile disease of unknown origin mainly associated with tropical regions, who are showing symptoms such as sudden fever with intense headaches and limb pain (see section 12 ‘Limitations’). The test procedure is not automated and requires no special training or qualification. The NADAL® Dengue NS1 Ag + IgG/IgM Test is designed for professional use only.
Dengue virus is a flavivirus transmitted primarily by tiger mosquitos Aedes aegypti and Aedes albopictus. It is widely distributed throughout the tropical and subtropical areas of the world and causes up to 100 million infections annually. Classic dengue infection is characterised by a sudden onset of fever, intense headache, myalgia, arthralgia and a rash. Primary dengue infection causes IgM to increase to a detectable level approximately 5 days after the onset of fever. IgM generally persists for 30 to 90 days. Most dengue patients in endemic regions have secondary infections, resulting in high levels of specific IgG prior to, or simultaneous with, IgM response. Therefore, the detection of specific anti-dengue IgM and IgG can also help to distinguish between primary and secondary infections. NS1 is one of 7 dengue virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles, where it is thought to be involved in viral replication. The rest of NS1 is found to be either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies produced in response to NS1 in viral infections can cross-react with cell surface antigens on epithelial cells and platelets. This may have implications in the development of dengue haemorrhagic fever.
More Information
More Information
SKU
532919N-10
Testformat
test cassette
Test evaluation
Provides a qualitative test result
Sample type
Serum, Whole Blood, Plasma
Detected parameter
Dengue Ag+IgG/IgM
Package size
10 individually packed test cassettes
Detection time
Test result after 15 minutes
Storage temperature
The test should be stored at 2 - 30 °C
CE-Label
Yes
Pathogentype
Viral infection
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