10 individually packed test cassettes for detection of C. difficile Toxin A&B antigens in human stool specimens
Package contents:
10 Test cassettes
10 specimen collection tubes with buffer
1 package insert
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The NADAL® C. difficile Toxin A/B Test is a rapid chromatographic immunoassay for the qualitative detection of Clostridium difficile (C. difficile) Toxin A&B antigens in human stool specimens to aid in the diagnosis of C. difficile infection.
C.difficile is an anaerobic, gram-positive, sporeforming bacterium. The key feature that enables it to persist in patients and physical environments for long periods of time and facilitates its transmission is the ability of C. difficile to form spores. C. difficile is transmitted through the fecal-oral route. Clostridium difficile is the principal pathogen related to antibiotic associated diarrhea and/or pseudomembranous colitis in hospitalized patients. Mature colonic bacterial flora in a healthy adult is generally resistant to C. difficile colonization. However, if the normal colonic flora is altered, resistance to colonization is lost. Thus, any factor associated with alteration of the normal enteric flora increases the risk of C. difficile colonization after exposure to antibiotics, especially those with broad-spectrum activity such as penicillins, cephalosporins and clindamycin. C. difficile can release two high-molecular-weight toxins, toxin A and toxin B. These are responsible for the clinical manifestations, which range from mild, self-limited watery diarrhea to fulminant pseudomembranous colitis, toxic megacolon, and death.
