10 individually packed test cassettes for detection of of Clostridium difficile Toxin A and Toxin B (C. difficile Toxins A&B), as well as Clostridium difficile glutamate dehydrogenase (C. difficile GDH) in human faecal specimens
Package contents:
10 test cassettes
10 disposable pipettes
10 specimen collection tubes with buffer
1 package insert
Exclusively for professional users
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The NADAL® C. difficile Toxin A/B+GDH Test is a lateral flow, immunochromatographic rapid test for the qualitative detection of Clostridium difficile Toxin A and Toxin B (C. difficile Toxins A&B), as well as Clostridium difficile glutamate dehydrogenase (C. difficile GDH) in human faecal specimens. The test is intended for use as an aid in the diagnosis of Clostridium difficile infection and is designed for professional use only.
C. difficile is an anaerobic gram-positive, spore-forming bacterium. The ability of C. difficile to form spores is the key feature which enables this bacterium to survive in patients and the physical environment for long periods, thereby facilitating its transmission. C. difficile is transmitted by the faecal-oral route. C. difficile is the principal pathogen related to antibioticrelated diarrhoea and/or pseudomembranous colitis in hospitalised patients. Mature colonic bacterial flora in a healthy adult is generally resistant to C. difficile colonisation. However, if the normal enteric flora is altered, resistance to colonisation is lost. Any factor associated with the alteration of the normal enteric flora increases the risk of C. difficile colonisation after exposure to antibiotics, especially those with broad-spectrum activity such as penicillins, cephalosporins and clindamycin. C. difficile releases two high-molecular-weight toxins: toxins A and B, which are responsible for the clinical manifestations ranging from mild, self-limiting, watery diarrhoea to fulminant pseudomembranous colitis, toxic megacolon and death. C. difficile GDH is an enzyme produced in large quantities by all toxigenic and non-toxigenic strains, making it an excellent biomarker.
