24 AFIAS test cassettes for the quantitative determination of myoglobin in human whole blood, serum or plasma.
Package contents:
24 AFIAS test cassettes
24 pipette tips
1 ID chip
1 package insert
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The AFIAS Myoglobin Test is a fluorescence immunoassay (FIA) for the quantitative determination of myoglobin in human whole blood/serum/plasma. The test is used as an aid in the diagnosis and monitoring of acute myocardial infarction (AMI). For in vitro diagnostic use only.
Myoglobin is a protein that binds oxygen. It is found in both skeletal and myocardial muscles. It acts as a transport protein and is involved in the diffusion of oxygen into muscle tissue. Myoglobin is a single-chain globular protein of 154 amino acids. It consists of a central iron-containing "haem" enclosed in a compact bundle-like or prism-like arrangement formed by the eight right-handed α-helices. As a cytoplasmic protein with a low molecular weight (of 17,699 daltons), myoglobin is released into the serum more rapidly than other cardiac markers when myocardial cells are damaged. The serum concentration of myoglobin rises above the normal range as early as 1 hour after acute myocardial infarction (AMI), reaches maximum in about 4 to 8 hours after onset, and returns to normal rapidly thereafter. Therefore, myoglobin is better as a cardiac marker for early diagnosis of AMI. However, the elevated myoglobin is not specific for AMI due to its large amounts in skeletal muscle. Despite its low clinical specificity and weak predictive value regarding AMI, myoglobin remains a promising cardiac marker when other markers such as creatine kinase isoenzyme-MB (CK-MB) and cardiac troponin-I (cTn-I) as well as other indicators such as clinical symptoms and ECG are also considered in the diagnosis/confirmation of AMI.
